L-GLUTAMINE

L-Glutamine is a nonessential amino acid that can be formed in the body from Glutamate, another amino acid.  Glutamine readily passes the blood-brain barrier, where it is transformed into Glutamic Acid, a neurotransmitter, and is then used by the brain as fuel.  It can also be converted in GABA (gamma aminobutyric), another neurotransmitter.  Glutamine has been suggested as a possible neurotransmitter itself.  About 90 percent of the dry weight of the brain consists of protein.  Approximately half of the amino acid composition of the brain is represented by Glutamic Acid and its derivatives, including L-Glutamine.

Glutamine is also involved in the formation of purine and pyrimadine nucleotides, the building blocks for RNA and DNA.  It has been implicated as the major energy producing substance in the small intestine for the transport of other nutrients and electrolytes into the body.  The balance between levels of Glutamate and Glutamine helps the body regulate ammonia balance.

L-Glutamine is reported to be clinically beneficial in cases of alcoholism, schizophrenia and senility.  It has also been shown to improve the IQ’s of mentally retarded children.  Ulcers heal more rapidly when glutamine is added to the diet, and glutamine helps prevent stomach ulcers and epileptic seizures.

VITAMINS A & D

Vitamin A is essential for vision, especially night vision, regulation of cell development and reproduction. It is a derivative of Beta-Carotene. Beta-Carotene can be broken down into three different forms of Vitamin A: Retinal (A), Retinal (A1), and Retinoic Acid.

Beta- Carotene is the only form of the three that is water soluble, which means that the body will combine it with water and remove it, lowering the possibility of toxic reactions when taken as a supplement.
Retinal, Vitamin A, is the most common form of the vitamin in supplemental usage. Retinal can be stored in the liver and may function in this form as a hormone. Vitamin A is also involved in reproduction and reproductive hormones.

Vitamin A1, retinal is the parent compound to the other two forms of Vitamin A. Retinal can also be used by the body to produce the eye’s visual pigmentation, opsin and rodopsin, which enable an individual to perceive through a complex series of chemical reactions.

Retinoic Acid is another form of Vitamin A produced from retinal. It has been implicated in affecting the expression of genes in both normal and malignant breast cancer cells in tissue cultures. Retinoic Acid is also involved in the growth of differentiation of many normal tissues in the human body, and has an important function in the synthesis of glycoprotein.

Vitamin D can be produced from cholesterol in the presence of sunlight, thus it is considered an essential nutrient only in people who are not exposed to the sun. There are several forms of Vitamin D that the body can use. Vitamin D3 is relied upon more by the body than Vitamin D2; although our bodies can use both.

The major biologic function of Vitamin D is to maintain normal blood levels of calcium and phosphorus. By promoting calcium absorption, Vitamin D helps to form and maintain strong bones. Vitamin D also works in concert with a number of other vitamins, minerals, and hormones to promote bone mineralization. Without Vitamin D, bones can become thin, brittle or misshapen.

NIACIN

Niacin plays many physiological roles, including the metabolism of cholesterol and the maintenance of nerve function. Niacin is also called Nicotinic Acid or Vitamin B3; it is the form of Vitamin B3 found in the plant kingdom. Niacin amide is Nicotinamide, created by the addition of a nitrogen group to the Niacin Molecule; it is also found in the animal kingdom. The major difference between Niacin and Niacin amide is Niacin’s ability to produce a reddening of the skin called a flush, which can be beneficial. The flush is the result of a release of histamine from the cells in the body. When histamine levels in the body are too high, they lead to irritability, bloating, congestion, rashes, sinus pressure, confusion and fatigue. Niacin amide does not cause this flushing reaction. Niacin also aids in lowering cholesterol levels.

Niacin can be produced from tryptophan, although the body does not produce enough Niacin in this manner. Therefore dietary intake is essential. When the body causes Niacin to become changed to its active form, it has many important metabolic functions. It aids the liver in drug detoxification, and is involved in fatty acid synthesis. It helps metabolize acetaldehyde, an alcohol byproduct. It is also involved in electron transport for the production of energy via respiratory chain.

Important in our B-Complex vitamin, Niacin reduces serum cholesterol. It interacts with cholesterol to produce cortisol, the body’s anti-inflammatory agent. When greater amounts of niacin are available for use by the Adrenal Cortex, the breakdown of reducing the secretion of certain inflammatory enzymes begins. It also stimulates the release of glucose, amino acids, and fatty acids into the blood plasma, making them available as energy sources and increasing the body’s healing rates.

Increased Cortisol production in response to an elevated histamine level will raise the body’s ability to withstand both physical and mental stress.
In addition, niacin interacts directly with histamine to alleviate allergies. In binding with histamines and removing it from the bloodstream, it not only helps to relieve symptoms, it actually reduces the chance of allergic outbreaks in the future.

B-COMPLEX

B-Complex vitamins are water-soluble vitamins that have a high degree of biological activity in the human system. The human body does not have the capability to synthesize them in the body to any large degree, so they must be obtained through the diet (B1), Riboflavin (B2), Riboflavin-5-Phosphate, Niacin (B3), Niacin amide (B3), Pantothenic Acid (B5), PABA, Pyridoxine Hydrochloride (B6), Choline Dihydrogen Citrate, Inositol, Hydroxycobamaline, Folic Acid and Biotin.

Most of B-Complex vitamins function as cofactors or enzyme-like complexes, but it would be too lengthy to mention their functions in this brochure. However, since our B-Complex has several ingredients not normally found in standard vitamin preparations, we will point out those differences here.
The first vitamin not found in most B vitamin preparation is Riboflavin-5-Phosphate, also known as Vitamin B2. Riboflavin is integral in the transfer of electrons for energy production. The form we have added to our preparation is the phosphoralated form of B2. Riboflavin is absorbed and enters into the bloodstream across the intestinal mucosa. By using the already phosphoralated form, a higher absorption rate can be achieved. We also include the regular Riboflavin so that normal absorption can also take place.

Another difference between our B-Complex and most commercial preparations is the addition of Vitamin B3 in two forms: Niacin and Niacin amide. Niacin, in its nonamide form, causes a reaction called a flush, which is characterized by red skin with a warm, tingling sensation. Some gastrointestinal stress may accompany this reaction. We have added Niacin because Niacin, in its pure form and not the amide form, has been shown to reduce serum cholesterol levels. By using both forms in our B-Complex, the user receives the benefits of Niacin’s cholesterol-lowering reaction with a minimal amount of flushing reaction.

We have added Choline Dihydrogencitrate to our B-Complex formula. By adding the citrate form instead of bitartrate form, we add citrate to the system. Citrate is a citric acid cycle (Krebbs Cycle) intermediary, a major energy producing cycle in the body.

We use a naturally occurring form of B12 called Hydroxocobamalin. This water-based form of Vitamin B12 is better for absorption. This can allow higher doses to be given by doctors without the fear of liver complications, as opposed to the industry standard Cyanocobamalin. Cyanocobamalin is a B12 molecule with cyanide attached to it, giving it a longer shelf life.

HISTAMINE

Histamine is an inflammatory agent, which is found naturally in the body and is an important factor in the auto immune response. When histamine levels are elevated above normal, however, a variety of allergic reactions may occur. This is because histamine causes a dilation of local blood vessels and increases the permeability of capillaries, causing an accumulation of fluid in the tissues. In Hay Fever, for example, the release of histamines causes fluid to leak rapidly into the tissues of the nose, swelling the construction of the bronchiolar smooth muscles of the lungs, making breathing difficult. Arthritic pain sufferers will be quick to tell you of the swelling around the joints, which makes movement painful and difficult.

All of the above allergen-regain reactions, as they are clinically known, are treated with prescription and over the counter medications, which affect the histamine pathways. Drugs like DIPENHYDRAMINE and PYRILAMINE prevent the release of histamine into circulation by blocking its receptors, thus keeping symptoms at bay. These drugs DO NOT prevent the over production of histamines, or break them down along the body’s metabolic pathways—they are a stop-gap measure only.

AMINO ACIDS

Amino acids are organic acids containing amine (ammonia-like) chemical group.  They are necessary for the synthesis of proteins, and are involved in other important biological processes, such as the formation of the brain’s neurotransmitters.  A strong amino acid balance increases antibodies, strengthens immune tissues, and helps the body fight infection.  Amino acids are divided into two categories:  essential and non-essential.  We require about twenty-two amino acids for normal metabolism and protein biosynthesis.  Of these amino acids, twelve can be manufactured by the body, so they are called “nonessential” amino acids.  There are, however, situations in which nonessential amino acids can become essential, such as severe physical trauma, which requires arginine to enable tissue repair processes.  The human body requires dietary intake of the remaining eight amino acids.  Because they cannot be manufactured by the human body, they are referred to as essential amino acids.